Journal of Medicinal Chemistry p. 7431 - 7444 (2019)
Update date:2022-08-16
Topics:
Zhu, Dongsheng
Huang, Huocong
Pinkas, Daniel M.
Luo, Jinfeng
Ganguly, Debolina
Fox, Alice E.
Arner, Emily
Xiang, Qiuping
Tu, Zheng-Chao
Bullock, Alex N.
Brekken, Rolf A.
Ding, Ke
Lu, Xiaoyun
A series of 2-amino-2,3-dihydro-1H-indene-5-carboxamides were designed and synthesized as new selective discoidin domain receptor 1 (DDR1) inhibitors. One of the representative compounds, 7f, bound with DDR1 with a Kd value of 5.9 nM and suppre
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