Practical synthesis of 2-(4-benzyl-piperazin-1-ylmethyl)-5…
benzylpiperazine 3 in the presence of K2CO3 gave 8 in 90 % yield (based on 7)
under mild conditions.
Conclusions
In conclusion, a convenient method for the synthesis of N-benzylpiperazine 3 was
developed, this method employing simple starting material (anhydrous piperazine)
instead of mono-protected (acyl, aroyl) piperazines, which is more convenient than
synthesized mono-substituted Benzylpiperazine derivatives. In addition, a practical
route for the synthesis of benzoquinone hydrochloride 8 has been achieved in good
yield. From the synthetic point of view, an approach based on the reactions with 7
looked promising for the synthesis of substituted CoQ analogues bearing a
heterocyclic ring. Hence, we believe that this experimentally simple approach could
be a useful addition to reported methods of obtaining CoQ homologues.
Acknowledgement This study was supported by the National Natural Science Foundation for Young
Scientists of China, the China Scholarship Council, the College students practice innovation training
program of Yancheng Teachers University, and the Natural Science Foundation of Yancheng Teachers
University.
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