European Journal of Medicinal Chemistry p. 458 - 466 (2015)
Update date:2022-08-30
Topics:
Redaelli, Marco
Mucignat-Caretta, Carla
Isse, Abdirisak Ahmed
Gennaro, Armando
Pezzani, Raffaele
Pasquale, Riccardo
Pavan, Valeria
Crisma, Marco
Ribaudo, Giovanni
Zagotto, Giuseppe
This work was aimed to the development of a set of new naphtoquinone derivatives that can act against glioma. The compounds were tested in order to find out their ability to inhibit the growth of glioma cells, and the results of these assays were correlated with electrochemical analysis and NMR-based reoxidation kinetic studies, suggesting that a redox mechanism underlies and may explain the observed biological behavior. In addition to a full description of the synthetic pathways, electrochemistry, NMR and single crystal X-ray diffraction data are provided.
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