8
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4
| CONCLUSIONS
135.
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We described the synthesis and characterization of two
complexes, [Cu4(Endc)4(phen)4]⋅7(H2O)⋅2(O) and [Mn2‐
(Endc)2(phen)2(H2O)2]⋅(H2O). The crystal structures of the
two complexes were determined using single‐crystal X‐ray
diffraction. The UV absorption and fluorescence spectra
obtained to study the interaction of the complexes with
DNA showed that the complexes had the ability to interact
with DNA. The ability of the complexes to cleave pBR322
DNA was investigated by agarose gel electrophoresis, indi-
cating the DNA‐binding affinity of complex 1 to be stronger
than that of complex 2. Apoptosis studies showed that the
complexes exhibited a certain cytotoxic activity against KB
cell line tested in general, with the longer the time, the higher
the apoptosis rate. A molecular docking study revealed that
the complexes had the capacity of DNA cleavage. Thus the
new synthesized Cu(II) and Mn(II) complexes may be poten-
tial antitumor agents due to their unique interaction mode
with DNA and their apoptotic activities.
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We gratefully acknowledge the Natural Science Foundation
of China (no. 21171118), the Distinguished Professor Project
of Liaoning Province and the science and technology special
fund of Shenyang City (F12‐151‐9‐00).
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SUPPORTING INFORMATION
Additional Supporting Information may be found online in
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