Journal of Fluorine Chemistry p. 59 - 63 (1996)
Update date:2022-08-16
Topics:
Dmowski, Wojciech
Piasecka-Maciejewska, Krystyna
A method for the preparation of 3,5-bis(trifluoromethyl)anisole (3) has been developed. Lithiation of 3 occurred exclusively at the position ortho to the CH3O group to give a thermally stable lithium derivative 6 which readily undergoes conventional reactions with a number of electrophiles. Formylation and carboxylation of 6 gave bis(trifluoromethyl) derivatives of salicylic aldehyde and salicylic acid 9-12 in good yields.
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