Journal of Polymer Science, Part A: Polymer Chemistry p. 99 - 107 (2016)
Update date:2022-08-11
Topics:
Huang, Ying
Sun, Rui
Luo, Qiaojie
Wang, Ying
Zhang, Kai
Deng, Xuliang
Zhu, Weipu
Li, Xiaodong
Shen, Zhiquan
In this study, a facile method to fabricate reduction-responsive core-crosslinked micelles via in situ thiol-ene "click" reaction was reported. A series of biodegradable poly(ether-ester)s with multiple pendent mercapto groups were first synthesized by melt polycondensation of diol poly(ethylene glycol), 1,4-butanediol, and mercaptosuccinic acid using scandium trifluoromethanesulfonate [Sc(OTf)3] as the catalyst. Then paclitaxel (PTX)-loaded core-crosslinked (CCL) micelles were successfully prepared by in situ crosslinking hydrophobic polyester blocks in aqueous media via thiol-ene "click" chemistry using 2,2′-dithiodiethanol diacrylate as the crosslinker. These PTX-loaded CCL micelles with disulfide bonds exhibited reduction-responsive behaviors in the presence of dithiothreitol (DTT). The drug release profile of the PTX-loaded CCL micelles revealed that only a small amount of loaded PTX was released slowly in phosphate buffer solution (PBS) without DTT, while quick release was observed in the presence of 10.0 mM DTT. Cell count kit (CCK-8) assays revealed that the reduction-sensitive PTX-loaded CCL micelles showed high antitumor activity toward HeLa cells, which was significantly higher than that of reduction-insensitive counterparts and free PTX. This kind of biodegradable and biocompatible CCL micelles could serve as a bioreducible nanocarrier for the controlled antitumor drug release.
View MoreZibo Linzi Darong Fine Chemical Co., Ltd
Contact:86-532-67773200; 15689126900
Address:Qidu town,Linzi district,Zibo city,Shandong province,China
Contact:
Address:ROOM 1715, No#345 Jin Xiang Road, Pudong District
Contact:86-571-85586718
Address:join hands science park,NO.4028 nanhuan road,hanghzou ,zhejiang,china
SHANGHAI ARCADIA BIOTECHNOLOGY LTD.
Contact:+86-21-61353236
Address:SUITE 901, BUILDING WENSLI, 1378 LU JIA BANG RD, SHANGAHI 200011, P.R.CHINA
Contact:86-931-8272767
Address:Room 602, No.461, Nanchang Road, Chengguan District, Lanzhou City, China PRC
Doi:10.1016/j.bmcl.2016.03.074
(2016)Doi:10.1039/b822905h
(2009)Doi:10.1016/S0040-4039(01)82369-8
(1974)Doi:10.1021/ol901545m
(2009)Doi:10.1007/s10593-016-1808-8
(2015)Doi:10.1246/bcsj.40.2203
(1967)