Synlett p. 693 - 697 (2004)
Update date:2022-08-11
Topics:
Koch, Guido
Loiseleur, Olivier
Altmann, Karl-Heinz
An efficient synthesis of the epothilone B derivative 26-fluoroepothilone B (1) was realized by early introduction of the synthetically demanding fluoromethyl epoxide function. The presence of a fluoro substituent results in a remarkable increase in the stability of the epoxide, which tolerates the wide range of reaction conditions required for the fragment coupling step and end game transformations.
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