Organic Letters
Letter
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12) See Supporting Information for a full list of tested conditions for
substrates 4a,b and 5a,b. A single crystal was grown by slow diffusion
of the solution of 8c in EtOAc/heptane mixture to determine its
absolute configuration. Supplementary crystallographic data for this
compound have been deposited at the Cambridge Crystallographic
the other substrates was assigned by analogy.
t
(
13) When Bu-PHOX (Pfaltz-Helmchen-Williams ligand) was used
as ligand in the reaction, no product was obtained in the case of azide-
substituted ketoesters. For cyano-substituted ketoesters, the product
was obtained in 94% yield, but in racemic form.
(
14) Preliminary experiments with linear ketoesters gave less than
0% conversion. Further investigations will be needed for this
challenging class of substrates.
1
D
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