Organic Letters
Detailed experimental procedures and spectroscopic
Letter
Benson, A. G.; Marrufo, L. D.; Madsen, H. M.; Hitchcock, J.; Owen, T.
J.; Christie, L.; Promo, M. A.; Hickory, B. S.; Alvira, E.; Naing, W.;
Blevis-Bal, R.; Messing, D.; Yang, J.; Mao, M. K.; Yalamanchili, G.;
Vonder Embse, R.; Hirsch, J.; Saabye, M.; Bonar, S.; Webb, E.;
Anderson, G.; Monahan, J. B. Discovery of PH-797804, a highly
selective and potent inhibitor of p38 MAP kinase. Bioorg. Med. Chem.
Lett. 2011, 21, 4066−4071.
AUTHOR INFORMATION
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Corresponding Author
ORCID
(11) Richeldi, L.; Yasothan, U.; Kirkpatrick, P. Pirfenidone. Nat. Rev.
Drug Discovery 2011, 10, 489−490.
Notes
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The authors declare no competing financial interest.
ACKNOWLEDGMENTS
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2(1H)-ones with Pentavalent Organobismuth Reagents under Copper-
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Catalyzed N-Arylation of 2-Pyridones Employing Diaryliodonium Salts
at Room Temperature. J. Org. Chem. 2016, 81, 7717−7724.
(16) Hirano, K.; Miura, M. A lesson for site-selective C-H
functionalization on 2-pyridones: radical, organometallic, directing
group and steric controls. Chem. Sci. 2018, 9, 22−32.
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́
We thank C. Fares, P. Philipps, and C. Wirtz (MPI KOFO) for
assistance with NMR structural assignment, as well as S. Marcus
and D. Kampen (MPI KOFO) for mass spectroscopy analysis.
We thank Dr. Olaf Ru
conversion) for providing the electrochemical setup. We thank
the Max-Planck-Institut fur Kohlenforschung and UCB Pharma
̈
diger (MPI for chemical energy
̈
for funding. W.H. thanks the Kwanjeong Educational
Foundation for funding.
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