4
Tetrahedron Letters
In conclusion, we have successfully developed a simple one-
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pot synthesis of 3-substituted isocoumarins via copper-catalyzed
cyclization of 2-bromobenzoic esters with terminal alkynes.
Compared to 2-bromobenzoic acids, 2-bromobenzoic esters are
more suitable for the annulation reaction, which show very high
efficiency and excellent regioselectivity. The easily accessible
substrates, ease of operation, satisfactory yields and excellent
regioselectivity make it very practical for the synthesis of the
useful 3-substituted isocoumarin derivatives.
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Acknowledgments
This work was financially supported by the National NSF of
China (Grant Nos. 21573065, 21172062, and 21273066) and the
NSF of Hunan Province (Grant No. 2016JJ1007) is appreciated.
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Supplementary data
Supplementary data including the experimental details, NMR
spectra, and analytical data of products 3 may be available free of
charge via the Internet or the author. Supplementary data
associated with this article can be found in the online version.
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