Organic Process Research and Development p. 2067 - 2073 (2016)
Update date:2022-08-11
Topics:
Rasal, Kalidas B.
Yadav, Ganapati D.
A novel, efficient, and scalable CO2 mediated synthesis of quinazoline-2,4(1H,3H)-dione was developed by a simple cyclization of 2-aminobenzonitrile with DMF in water as the solvent. This is the first report of its kind. DMF was used as the necessary carbon source in the synthesis of quinazoline-2,4(1H,3H)-dione. This synthetic protocol is very efficient; it gives >99% conversion with excellent selectivity. The product was isolated by filtration because of the highly insoluble nature of quinazoline-2,4(1H,3H)-dione in water. The co-product, dimethyl amine, also has industrial importance, and the CO2 that is used can be recycled. This protocol has wide-spread applications in the syntheses of benzimidazole and benzothiazole.
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Doi:10.1016/0277-5387(96)00200-8
(1996)Doi:10.1021/acscatal.6b02097
(2016)Doi:10.1007/s10973-008-9342-2
(2009)Doi:10.1021/op049809c
(2005)Doi:10.1016/S0040-4039(01)01728-2
(2001)Doi:10.1021/ja00286a029
(1986)