R. White et al
Anandamide relaxation of rat coronary artery
929
FELDER, C.C., JOYCE, K.E., BRILEY, E.M., MANSOURI, J., MACKIE,
K., BLOND, O., LAI, Y., MA, A.L. & MITCHELL, R.L. (1995).
Comparison of the pharmacology and signal transduction of the
human cannabinoid CB1 and CB2 receptors. Mol. Pharmacol.,
48, 443 ± 450.
FLEMING, I., SCHERMER, B., POPP, R. & BUSSE, R. (1999). Inhibition
of the production of endothelium-derived hyperpolarizing factor
by cannabinoid receptor agonists. Br. J. Pharmacol., 126, 949 ±
960.
FRANCO-CERECEDA, A., SARIA, A. & LUNDBERG, J.M. (1989).
Dierential release of calcitonin gene-related peptide and
neuropeptide Y from the isolated heart by capsaicin, ischaemia,
nicotine, bradycardia and oubain. Acta Physiol. Scand., 135,
173 ± 187.
FULTON, D. & QUILLEY, J. (1998). Evidence against anandamide as
the hyperpolarizing factor mediating the nitric oxide-indepen-
dent coronary vasodilator eect of bradykinin in the rat. J.
Pharmacol. Exp. Ther., 286, 1146 ± 1151.
LANGTON, P.D., NELSON, M.T., HUANG, Y.
&
STANDEN, N.B.
(1991). Block of calcium-activated potassium channels in
mammalian arterial myocytes by tetraethylammonium. Am. J.
Physiol., 260, H927 ± H934.
OTLEY, C.E., RICHARDSON, P.J. & HILEY, C.R. (1996). Adenosine
receptors in the coronary artery of the rat. Br. J. Pharmacol., 119,
73P.
PRATT, P.F., HILLARD, C.J., EDGEMOND, W.S. & CAMPBELL, W.B.
(1998). N-arachidonylethanolamide relaxation of bovine cor-
onary artery is not mediated by CB1 cannabinoid receptor. Am.
J. Physiol., 43, H375 ± H381.
RALEVIC, V, KENDALL, D.A., RANDALL, M.D., ZYGMUNT, P.M.,
MOHAVED, P. & HOGESTATT, E.D. (2000). Vanilloid receptors on
capsaicin-sensitive sensory nerves mediate relaxation to metha-
nandamide in the rat isolated mesenteric arterial bed and small
mesenteric arteries. Br. J. Pharmacol., 130, 1483 ± 1488.
RALEVIC, V. & KENDALL, D.A. (2001). Cannabinoid inhibition of
capsaicin-sensitive sensory neurotransmission in the rat mesen-
teric arterial bed. Eur. J. Pharmacol., 418, 117 ± 125.
RANDALL, M.D., ALEXANDER, S.P.H., BENNETT, T., BOYD, E.A.,
FRY, J.R., GARDINER, S.M., KEMP, P.A., McCULLOCH, A.I. &
KENDALL, D.A. (1996). An endogenous cannabinoid as an
endothelium-derived vasorelaxant. Biochem. Biophys. Res. Com-
mun., 229, 114 ± 120.
GALVEZ, A., GIMENEZ-GALLEGO, G., REUBEN, J.P., ROY-CON-
TANCIN, L., FEIGENBAUM, P., KACZOROWSKI, G.J. & GARCIA,
M.L. (1990). Puri®cation and characterization of a unique,
potent, peptidyl probe for the high conductance calcium-
activated potassium channel from venom of the scorpion Buthus
tamulus. J. Biol. Chem., 265, 11083 ± 11090.
GEBREMEDHIN, D., LANGE, A.R., CAMPBELL, W.B., HILLARD, C.J.
HARDER, D.R. (1999). Cannabinoid CB1 receptor of cat
RANDALL, M.D. & KENDALL, D.A. (1997). Involvement of a
&
cannabinoid in endothelium-derived hyperpolarizing factor-
mediated coronary vasorelaxation. Eur. J. Pharmacol., 335,
205 ± 209.
cerebral arterial muscle functions to inhibit L-type Ca2+ channel
current. Am. J. Physiol., 276, H2085 ± H2093.
HOLLAND, M., CHALLISS, R.A.J., STANDEN, N.B. & BOYLE, J.P.
(1999). Cannabinoid CB1 receptors fail to cause relaxation, but
couple via Gi/Go to the inhibition of adenylyl cyclase in carotid
artery smooth muscle. Br. J. Pharmacol., 128, 597 ± 604.
HOSOHATA, Y., QUOCK, R.M., HOSOHATA, K., MAKRIYANNIS, A.,
CONSROE, P., ROESKE, W.R. & YAMAMURA, H.I. (1997). AM630
antagonism of cannabinoid-stimulated [35S]GTP gamma-S bind-
ing in the mouse brain. Eur. J. Pharmacol., 321, R1 ± R3.
JARAI, Z., WAGNER, J.A., VARGA, K., LAKE, K.D., COMPTON, D.R.,
MARTIN, B.R., ZIMMER, A.M., BONNER, T.I., BUCKLEY, N.E.,
MEZEY, E., RAZDAN, R.K., ZIMMER, A. & KUNOS, G. (1999).
Cannabinoid-induced mesenteric vasodilation through an en-
dothelial site distinct from CB1 or CB2 receptors. Proc. Natl.
Acad. Sci. U.S.A., 96, 14136 ± 14141.
ROSS, R.A., BROCKIE, H.C., STEVENSON, L.A., MURPHY, V.L.,
TEMPLETON, F., MAKRIYANNIS, A. & PERTWEE, R.G. (1999).
Agonist-inverse agonist characterization at CB1 and CB2
cannabinoid receptors of L759633, L759656, and AM630. Br.
J. Pharmacol., 126, 665 ± 672.
SHOWALTER, V.M., COMPTON, D.R., MARTIN, B.R. & ABOOD, M.E.
(1996). Evaluation of binding in a transfected cell line expressing
a
peripheral cannabinoid receptor (CB2): identi®cation of
cannabinoid receptor subtype selective ligands. J. Pharmacol.
Exp. Ther., 278, 989 ± 999.
WHITE, R. & HILEY, C.R. (1997). A comparison of EDHF-mediated
and anandamide-induced relaxations in the rat isolated mesen-
teric artery. Br. J. Pharmacol., 122, 1573 ± 1584.
WHITE, R. & HILEY, C.R. (1998a). The actions of some cannabinoid
receptor ligands in the rat isolated mesenteric artery. Br. J.
Pharmacol., 125, 533 ± 541.
WHITE, R. & HILEY, C.R. (1998b). The actions of the cannabinoid
receptor antagonist, SR 141716A, in the rat isolated mesenteric
artery. Br. J. Pharmacol., 125, 689 ± 696.
KALLNER, G., OWALL, A.
& FRANCO-CERECEDA, A. (1999).
Myocardial out¯ow of calcitonin gene-related peptide in relation
to metabolic stress during coronary artery bypass grafting
without cardiopulmonary bypass. J. Thorc. Cardiovasc. Surg.,
117, 447 ± 453.
KOUTEK, B., PRESTWICH, G.D., HOWLETT, A.C., CHIN, S.A.,
& DEUTSCH, D.G. (1994).
YEON, D., KWON, S., LEE, Y., LEEM, J., NAM, T. & AHN, D. (2001).
Capsaicin-induced relaxation in rabbit coronary artery. J. Vet.
Med. Sci., 63, 499 ± 503.
ZYGMUNT, P.M., PETERSSON, J., ANDERSSON, D.A., CHUANG,
H.H., SORGARD, M., DI MARZO, V., JULIUS, D. & HOGESTATT,
E.D. (1999). Vanilloid receptors on sensory nerves mediate the
vasodilator action of anandamide. Nature, 400, 452 ± 457.
SALEHANI, D., AKHAVAN, N.
Inhibitors of arachidonyl ethanolamide hydrolysis. J. Biol.
Chem., 269, 22937 ± 22940.
LAGNEUX, C.
& LAMONTAGNE, D. (2001). Involvement of
cannabinoids in the cardioprotection induced by lipopolysac-
charide. Br. J. Pharmacol., 132, 793 ± 796.
LAKE, K.D, COMPTON, D.R., VARGA, K., MARTIN, B.R. & KUNOS,
G. (1997). Cannabinoid-induced hypotension and bradycardia in
rats is mediated by CB1-like cannabinoid receptors. J. Pharma-
col. Exp. Ther., 281, 1030 ± 1037.
(Received June 13, 2001
Revised August 7, 2001
Accepted August 9, 2001)
LAN, R.X., LIU, Q., FAN, P.S., LIN, S.Y., FERNANDO, S.R.,
MCCALLION, D., PERTWEE, R. & MAKRIYANNIS, A. (1999).
Structure-activity relationships of pyrazole derivatives as
cannabinoid receptor antagonists. J. Med. Chem., 42, 769 ± 776.
British Journal of Pharmacology vol 134 (4)