EXCLI Journal 2017;16:448-463 – ISSN 1611-2156
Received: September 15, 2016, accepted: March 13, 2017, published: April 03, 2017
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also found that they were able to alter the ep-
igenetic pathways evident from HDAC inhi-
bition. In addition, we observed a reduction in
ACF and adenocarcinoma formation in the
colon of animals treated with the test com-
pounds. Furthermore, they were able to lower
the increased levels of TNF-α suggesting their
role in inflammation. These results demon-
strated the efficacy of the compounds against
colon adenocarcinoma, providing a potential
lead for anticancer drug development.
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Acknowledgements
The work was supported by a Grant
SR/SO/HS-0282/2012 obtained from the Sci-
ence and Engineering Research Board, De-
partment of Science and Technology (DST-
SERB). The authors would like to
acknowledge All India Council for Technical
Education (AICTE) for providing funds for
the procurement of Flow cytometer used in
the study. We thank the Department of Phar-
macology, Manipal College of Pharmaceuti-
cal Sciences, Manipal University, India for
providing necessary facilities to carry out the
present work.
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Conflict of interest
The authors declare that they have no con-
flict of interest to disclose.
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and the promise of epigenetic (and more) treatments for
cancer. Nat Rev Cancer. 2006;6:38-51.
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