Synthetic Communications p. 1899 - 1915 (2007)
Update date:2022-08-11
Topics:
Li, Zhong
Yang, Dingqiao
Gabathuler, Reinhard
Chen, Qingqi
Novel heterobifunctional cross-linkers with an isocyanato group, a protected carboxylic group, and a linear chain spacer are synthesized in high yield by coupling monofunctionalized PEG with 1,6-diisocyanatohexane. The isocyanato groups of those linkers are highly reactive and are efficient reagents to couple with the hydroxy groups of 10-hydroxycamptothecin and SN-38 under mild conditions to give a useful precursor for the synthesis of their bioconjugates with proteins such as melanotransferrin p97. Copyright Taylor & Francis Group, LLC.
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