Letters
Journal of Medicinal Chemistry, 2007, Vol. 50, No. 26 6461
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of these compounds might act via stimulation of stress signaling,
which can dramatically increase cellular NAD+,24 or some of
them might be degraded to nicotinamide or nicotinic acid,15,18
which can be converted to NAD+ via Nrk-independent path-
ways. It is concluded that NR and derivatives could provide an
effective pharmacological means to increase NAD+ concentra-
tions in mammalian cells and tissues and may aid in the
investigation of NAD+ signaling in cells and how NAD+
impacts survival, proliferation, differentiation, and other physi-
ological processes.
Acknowledgment. This work has been supported in part
by a grant to Anthony Sauve from the National Institutes of
Health (DK R01 73466-01). Anthony Sauve is an Ellison
Medical Foundation New Scholar in Aging (2007). Anthony
Sauve is a consultant for Sirtris Pharmaceuticals and has
financial interests related to compounds discussed in this study.
Supporting Information Available: Experimental procedures
and compound characterization are available in a PDF file. This
material is available free of charge via the Internet at http://
pubs.acs.org.
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