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New Journal of Chemistry
Page 7 of 9
DOI: 10.1039/C6NJ00612D
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ARTICLE
stirring. The reaction mixture was stirred at room temperature 12. S. Priyadarshini, P. A. Joseph, P. Srinivas, H. Maheswaran,
for 5 h. During this process, the colour of the mixture changed
to light yellow. Afterward, the solid product was isolated by
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centrifugation and washed with methanol several times to 13. F. Liu and D. Ma, J. Org. Chem. 2007, 72, 4844-4850.
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confirmed by XRD analysis of the final product.
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15. A. R. Hajipour, E. Boostani and F. Mohammadsaleh, RSC
General process for sonogashira cross-coupling reaction
Adv. 2015, 5, 94369-94374.
Aryl halide (1 mmol), phenylacetylene (1.1 mmol, 0.11 ml), 16. Y. F. Wang, W. Deng, L. Liu and Q. X. Guo, Chin. Chem.
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Lett. 2005, 16, 1197.
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17. D. J. Cole-Hamilton, Science. 2003, 299, 1702-1706.
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an oil bath at 135-140 °C and followed by gas chromatography 3385-3466.
(GC) and thin-layer chromatography (TLC). After the reaction 19. Y.-M. Lu, H.-Z. Zhu, W.-G. Li, B. Hu and S.-H. Yu, J. Mater.
was complete, or when the progress of the reaction had Chem. A. 2013, , 3783-3788.
stopped, the cooled resulting mixture was diluted by adding 20. D. De Vos, I. F. Vankelecom and P. A. Jacobs, Chiral
,
1
with EtOAC and H2O. The coupled product was extracted with
EtOAc and the organic phase was dried over CaCl2, filtered and
catalyst immobilization and recycling, John Wiley & Sons.
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concentrated. The residue could be purified by silica gel 21. N. E. Leadbeater and M. Marco, Chem. Rev. 2002, 102
column chromatography (hexane:EtOAc). The arylalkyne 3217-3274.
,
products were known compounds and were characterized by 22. N. J. Costa and L. M. Rossi, Nanoscale. 2012, 4, 5826-5834.
1H NMR, 13C NMR and FTIR.
23. A. L. Isfahani, I. Mohammadpoor-Baltork, V. Mirkhani, A.
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Acknowledgements
24. B. Singh, S. L. Jain, B. S. Rana, P. K. Khatri, A. K. Sinha and
B. Sain, ChemCatChem. 2010,
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2, 1260-1264.
We gratefully acknowledge the funding support received for
this project from the Isfahan University of Technology (IUT), IR
Iran, Further financial support from the center of Excellence in
Sensor and Green Chemistry Research (IUT) is gratefully
acknowledged.
5
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