Journal of labelled compounds and radiopharmaceuticals p. 623 - 629 (1998)
Update date:2022-08-15
Topics:
Johnstroem, Peter
Fredriksson, Anna
Thorell, Jan-Olov
Stone-Elander, Sharon
[Methoxy-11C]PD153035, a potent and specific inhibitor of the EGF receptor tyrosine kinase, was prepared by O-alkylation of O-desmethyl PD153035 with [11C]methyl iodide in DMF. The radiochemical incorporation of [11C]CH3I was on the order of 45%. The mean specific activity obtained at end-of-synthesis (EOS) was 26 GBq/μmol (n=3; range 20-36 GBq/μmol) and total synthesis time was 45-50 minutes including formulation.
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