Bioorganic Chemistry p. 433 - 443 (2018)
Update date:2022-08-11
Topics:
Xie, Dandan
Shi, Jing
Zhang, Awei
Lei, Zhiwei
Zu, Guangcheng
Fu, Yun
Gan, Xiuhai
Yin, Limin
Song, Baoan
Hu, Deyu
A series of novel quinazoline derivatives containing a dithioacetal moiety were designed and synthesized, and their structures were characterized by 1H nuclear magnetic resonance, 13C nuclear magnetic resonance, and high-resolution mass spectrometry. Bioassay results indicated that compound 4b exhibited remarkable protective activity against cucumber mosaic virus (CMV, EC50 = 248.6 μg/mL) and curative activity against potato virus Y (EC50 = 350.5 μg/mL), which were better than those of ningnanmycin (357.7 μg/mL and 493.7 μg/mL, respectively). Moreover, compound 4b could increase the chlorophyll content in plants, improve photosynthesis, and effectively induce tobacco anti-CMV activity.
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Doi:10.1016/j.phytochem.2020.112333
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