Synthetic Communications p. 3084 - 3089 (2021)
Update date:2022-08-10
Topics:
Yang, Yuyan
Li, Hua
You, Zhonglin
Zhang, Xingxian
A novel and enantioselective synthesis of (S)-2-pipecolic acid (5) has been achieved from Oppolzer’s sultam (1) and ethyl N-(diphenylmethylene)glycinate (2) as readily available starting materials. The highly stereoselective alkylation of chiral glycine intermediate (3) with 1,4-dibromobutane afforded the key backbone of (S)-2-pipecolic acid (5) in one-step that was utilized into the preparation of the local anesthetics mepivacaine, ropivacaine and bupivacaine.
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Doi:10.1021/ja505286j
(2014)Doi:10.1016/j.tetlet.2010.03.097
(2010)Doi:10.1016/j.tetlet.2005.12.066
(2006)Doi:10.1016/j.jorganchem.2003.10.004
(2004)Doi:10.1002/(SICI)1521-3773(19981204)37:22<3124::AID-ANIE3124>3.0.CO;2-1
(1998)Doi:10.1016/S0022-328X(00)81768-4
(1972)