16
Tetrahedron
and 1.8 Hz, 1H), 2.78 (d, J = 4.8 Hz, 3H), 2.44-2.33 (m, 1H),
Serisawa, K.; Abe, T.; Matsuda, F.; Suzuki, M.; Okino, T. Angew. Chem.
ACCEPTED MANUSCRIPT
Int. Ed. 2014, 53, 3909.
2.30 (dt, J = 14.1 and 1.8 Hz, 1H), 2.15-1.94 (m, 2H), 1.94-1.85
(m, 1H), 1.72-1.55 (m, 2H), 1.48-1.20 (m, 5H), 1.10 (d, J = 6.9
Hz, 3H), 0.9 (s, 9H); 13C NMR (CDCl3, 75 MHz): δ 177.5, 140.9,
114.5, 76.6, 41.9, 37.6, 35.1, 34.4, 30.2, 27.7, 27.4, 26.6, 26.1,
18.3; IR (ATR): νmax 3312, 2935, 1650, 1555, 1411, 1069, 756
cm-1; ESIHRMS m/z calcd for C16H3135ClNO2 [M+H]+ 304.2038,
found 304.2039.
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Acknowledgments
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Our work was supported by the Université libre de Bruxelles
(ULB), the FNRS (Incentive Grant for Scientific Research n°
F.4530.13), and the Fédération Wallonie-Bruxelles (ARC
Consolidator 2014-2019). AN and KJ respectfully acknowledge
the Fonds pour la formation à la Recherche dans l’Industrie et
dans l’Agriculture (F.R.I.A.) and the Ministère de la Recherche
for graduate fellowships. We are indebted to Prof. Alexandre
Alexakis (University of Geneva) for his remarkably precious
advices for the carbocupration step.
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