Organic and Biomolecular Chemistry p. 9423 - 9430 (2016)
Update date:2022-08-11
Topics:
Zhou, Bei
Liu, Zheng-Fen
Deng, Guo-Gang
Chen, Wen
Li, Min-Yan
Yang, Li-Juan
Li, Yan
Yang, Xiao-Dong
Zhang, Hong-Bin
The synthesis of a series of novel N-substituted tetrahydro-β-carboline-imidazolium salt derivatives is presented. The biological properties of the compounds were evaluated in vitro against a panel of human tumor cell lines. The results suggest that the benzimidazole ring and 1-(naphthalen-2-yl)ethan-1-one or 2-naphthylmethyl substituent at the imidazolyl-3-position were vital for modulating cytotoxic activity. Compound 41 was observed as a potent derivative with IC50 values of 3.24-8.78 μM and exhibited cytotoxic activity selectively against HL-60, A-549 and MCF-7 cell lines. Meanwhile, high inhibitory activities selectively against HL-60 and MCF-7 cell lines were observed for compound 51. Moreover, compound 51 was able to induce G1 phase cell cycle arrest and apoptosis in MCF-7 cells. The cytotoxicity of compound 51 against human normal lung epithelial cell line BEAS-2B was further evaluated.
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Doi:10.1016/j.tetlet.2017.07.044
(2017)Doi:10.1016/0022-2860(83)85043-1
(1983)Doi:10.1016/j.dyepig.2013.09.002
(2014)Doi:10.1016/0223-5234(91)90034-K
(1991)Doi:10.1021/acs.joc.5b00246
(2015)Doi:10.1021/acs.macromol.6b01512
(2016)