SHAH ET AL.
13 of 14
ꢀ
[2] Ü. Yılmaz, S. Tekin, N. Bugday, K. Yavuz, H. Küçükbay,
S. Sandal, Inorg. Chim. Acta 2019, 495, 118977.
[3] M. Frezza, S. Hindo, D. Chen, A. Davenport, S. Schmitt,
D. Tomco, Q. P. Dou, Curr. Pharm. Des. 2010, 16, 1813.
[4] C. S. Allardyce, P. J. Dyson, Dalton Trans. 2016, 45, 3201.
[5] R. Gup, C. Gokce, N. Dilek, J. Photochem. Photobiol. B 2015,
144, 42.
3.9 | Morphological aspects in breast
cancer treatment
Proceeding from responsibility of researches, the
researchers must do hard to find a good antitumor drug
particularly to treat breast cancer which cause the death
for many women. In vitro screening towards MCF-7 cell
line was of interest regarding the new complexes
(Figure S17). A series of concentrations were tested
(100, 50, 25, 12.6 and 6.25 μM) during 48 h of monitoring,
to estimate IC50 values (Table S5). This estimation was
carried out for the relation between concentration and
cell viability and in comparison with doxorubicin (refer-
ence drug). Excellent toxicity was recorded with the
Co(II)–3e complex, while strong toxicity to another mod-
erate was recorded with Co(II)–3b and Co(II)–3c com-
plexes. Furthermore, the images of treated cell lines
(Figure 6) displayed changes in morphology for the vari-
ous concentrations. Also, cells changed to spherical
shape, which points to an extent of permeability from cell
membrane and reduced proliferation. This feature was
clearly noticed with the Co(II)–3e complex at 100 and
50 μM, which displayed shrinkage for cell shape, round-
ing and detachment from the plate surface.
[6] S. Mathur, S. Tabassum, Cent. Eur. J. Chem. 2006, 3, 502.
[7] P. Santhakumar, M. N. Arumugham, Int. J. Chem. Anal. Sci.
2012, 3, 1513.
[8] C. Santini, M. Pellei, G. G. Lobbia, S. Alidori, M. Berrettini,
D. Fedeli, Inorg. Chim. Acta 2004, 357, 3549.
[9] (a)N. Muhammad, Z. Guo, Curr. Opin. Chem. Biol. 2014, 19,
144. (b)S. Ali, V. Singh, P. Jain, V. Tripathi, J. Saudi Chem.
Soc. 2019, 23, 52.
[10] Z. Zhao, J. Zhang, S. Zhi, W. Song, J. Zhao, J. Inorg. Biochem.
2019, 197, 110696.
[11] T. W. Failes, T. W. Hambley, Dalton Trans. 2006, 15, 1895.
[12] R. K. Singh, S. Kumar, D. N. Prasad, T. R. Bhardwaj, Eur.
J. Med. Chem. 2018, 151, 401.
[13] F. Saad, N. El-Metwaly, T. A. Farghaly, M. Elghalban,
R. Shah, G. Al-Hazmi, K. Saleh, M. Alfaifi, J. Mol. Liq. 2017,
229, 614.
[14] I. Althagafi, N. M. El-Metwally, M. Elghalban, T. A. Farghaly,
A. M. Khedr, Bioinorg. Chem. Appl. 2018, 2018, 1.
[15] J. H. Al-Fahemi, F. A. Saad, N. M. El-Metwaly, T. A. Farghaly,
M. G. Elghalban, K. A. Saleh, G. A. Al-Hazmi, Appl. Organo-
metal. Chem. 2017, 31, 3787.
[16] F. K. El-Baz, R. A. Hussein, K. Mahmoud, S. M. Abdo,
Phytother. Res. 2018, 32, 298.
[17] T. Mosmann, J. Immunol. Methods 1983, 65, 55.
[18] M. I. Thabrew, R. D. Hughes, I. G. McFarlane, J. Pharm.
Pharmacol. 1997, 49, 1132.
[19] R. Dennington, T. Keith, J. Millam, GaussView, Version 4.1.2,
Semichem Inc., Shawnee Mission, KS, 2007.
[20] U. El-Ayaan, N. M. El-Metwally, M. M. Youssef, S. A. A. El
Bialy, Spectrochim. Acta A 2007, 68, 1278.
[21] R. K. Ray, G. R. Kauffman, Inorg. Chem. Acta 1990, 173, 207.
[22] K. H. Mashat, B. A. Babgi, M. A. Hussien, M. N. Arshad,
M. H. Abdellattif, Polyhedron 2019, 158, 164.
[23] M. H. Abdellattif, M. A. Hussien, E. Alzahrani, Int. J. Pharm.
Sci. Res. 2018, 9, 1000.
4 | CONCLUSIONS
A new series of Co(II)–thioanhydride complexes were pre-
pared and elucidated. Two distinct structural forms
(square-planar and octahedral) were proposed based on
results of UV–visible spectroscopic and magnetic measure-
ments. Non-conducting characteristic was found for many
complexes, which coincides with coordinating tendency of
acetate group. Estimated physical parameters, studied from
a comparative point of view, suggest the superiority of the
Co(II) complexes over the free ligands. MOE docking was
executed against three selected proteins: 3nwh, 3ee2 and
3s7s. Promising inhibition activity was clearly apparent for
the complexes through the interaction data. In vitro study
concerning the complexes was carried out against MCF-7
cell line, and also photographed for conformation. Most of
the new complexes served as outstanding antitumor agents,
with activity exceeding that of the reference drug itself.
[24] I. Althagafi, N. El-Metwaly, T. A. Farghaly, Molecules 2019, 24,
1741.
[25] A. I. Vogel, Text Book of Quantitative Inorganic Analysis,
Longman, London 1986.
[26] W. J. Geary, J. Coord. Chem. Rev. 1971, 7, 81.
[27] F. A. Saad, J. H. Al-Fahemi, H. El-Ghamry, A. M. Khedr,
M. G. Elghalban, N. M. El-Metwaly, J. Therm. Anal. Calorim.
2018, 131, 1249.
[28] L. Almazroia, R. Shah, N. El-Metwaly, T. A. Farghaly, Res.
Chem. Intermed. 2019, 45, 1943.
[29] K. S. Abu-Melha, N. M. El-Metwally, Spectrochim. Acta A
2008, 70, 277.
[30] N. M. El-Metwaly, R. M. El-shazly, I. M. Gabr, A. A. El-Asmy,
Spectrochim. Acta A 2005, 61, 1113.
ORCID
[31] A. B. P. Lever, Inorganic Electronic Spectroscopy, Elsevier,
Amsterdam 1986.
REFERENCES
[1] M. Vojtek, M. P. M. Marques, Drug Discov. Today 2019, 24,
[32] N. M. El-Metwally, G. A. A. Al-Hazmi, Spectrochim. Acta A
2013, 107, 289.
1044.