Organic Process Research and Development p. 1274 - 1281 (2015)
Update date:2022-08-11
Topics:
Moccia, Maria
Cortigiani, Mauro
Monasterolo, Claudio
Torri, Federica
Del Fiandra, Claudia
Fuller, Geoffrey
Kelly, Brian
Adamo, Mauro F. A.
Herein is reported the development of a new process to manufacture (S)-pregabalin. The method comprises six steps, run under the catalysis of a recyclable polymer bound phase transfer catalyst, and afforded (S)-pregabalin in overall 54% yield, starting from building blocks acetylacetone, isovaleraldehyde, and nitromethane.
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