[21] A. Cabré, X. Verdaguer, A. Riera, Enantioselective Synthesis of β-Methyl Amines via
Iridium-Catalyzed Asymmetric Hydrogenation of N-Sulfonyl Allyl Amines, Adv. Synth.
Catal. 361 (2019) 4196-4200.
[22] M. N. Romanelli, M. D. Lungo, L. Guandalini, M. Zobeiri, A. Gyꢄkeres, T. ꢅrpꢀdffy-
Lovas, I. Koncz, L. Sartiani, G. Bartolucci, S. Dei, D. Manetti, E. Teodori, T. Budde, E.
Cerbai, EC18 as a Tool To Understand the Role of HCN4 Channels in Mediating
Hyperpolarization-Activated Current in Tissues, ACS Med. Chem. Lett. 10 (2019) 584-
589.
[23] R. Wang, R. X. Jin, Z.Y. Qin, K. J. Bian, X. S. Wang, Novel and facile synthesis of 1-
benzazepines via copper-catalyzed oxidative C(sp3)-H/C(sp2)-H cross-coupling, Chem.
Commun. 53 (2017) 12229-12232.
[24] H. J. Böhm, A. Flohr, M. Stahl, Scaffold hopping, Drug Discov. Today: Technologies 1
(2004) 217–224.
[25] P. A. Harris, J. M. Marinis, J. D. Lich, S. B. Berger, A. Chirala, J. A. Cox, P. M. Eidam,
J. N. Finger, P. J. Gough, J. U. Jeong, J. Kang, V. Kasparcova, L. K. Leister, M. K.
Mahajan, G. Miller, R. Nagilla, M. T. Ouellette, M. A. Reilly, A. R. Rendina, E. J. Rivera,
H. H. Sun, J. H. Thorpe, R. D. Totoritis, W. Wang, D. Wu, D. Zhang, J. Bertin, R. W.
Marquis, Identification of a RIP1 Kinase Inhibitor Clinical Candidate (GSK3145095) for
the Treatment of Pancreatic Cancer, ACS Med. Chem. Lett. 10 (2019) 857-862.
[26] B. M. Smith, J. M. Smith, J. H. Tsai, J. A. Schultz, C. A. Gilson, S. A. Estrada, R. R.
Chen, D. M. Park, E. B. Prieto, C. S. Gallardo, D. Sengupta, P. I. Dosa, J. A. Covel, A.
Ren, R. R. Webb, N. R. A. Beeley, M. Martin, M. Morgan, S. Espitia, H. R. Saldana, C.
Bjenning, K. T. Whelan, A. J. Grottick, F. Menzaghi, W. J. Thomsen, Discovery and
Structure-Activity Relationship of (1R)-8-Chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-
benzazepine (Lorcaserin), a Selective Serotonin 5-HT2C Receptor Agonist for the
Treatment of ObesityJ. Med. Chem. 51 (2008) 305–313.
[27] S. Thum, D. Schepmann, E. Ayet, M. Pujol, F. R. Nietoc, S. M. Ametamey, B. Wünsch,
Tetrahydro-3-benzazepines with fluorinated side chains as NMDA and σ1 receptor
antagonists: Synthesis, receptor affinity, selectivity and antiallodynic activity Eur. J. Med.
Chem. 177 (2019) 47-62.
[28] L. Ouchakour, R. A: Ábrahámi, E. Forró, M. Haukka, F. Fülöp, L. Kiss, Stereocontrolled
Synthesis of Fluorine-Containing Piperidine γ-Amino Acid Derivatives, A De Novo
Synthetic Route to 1,2,3,4-Tetrahydroisoquinoline Derivatives, Eur. J. Org. Chem. (2019)
2202–2211.
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