ACS Medicinal Chemistry Letters
Letter
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AUTHOR INFORMATION
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Corresponding Author
ORCID
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Author Contributions
The manuscript was written through contributions of all authors.
M.L. and S.A.N. contributed equally.
Notes
The authors declare no competing financial interest.
⊥Joint first authors.
ACKNOWLEDGMENTS
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The authors acknowledge support from the Singapore Ministry
of Health National Medical Research Council TCR Flagship
grant NMRC/TCR/011-NUHS/2014 and Centre Grant
“MINE”, ResearchCore#4NMRC/CG/013/2013 toT.D., Min-
istry of Education Academic Research Fund R148000234114 to
M.-L.G., and graduate scholarships to M.L., S.A.N. This work is
part of the Singapore Program of Research Investigating New
Approaches to Treatment of Tuberculosis (SPRINT TB) led by
Dr N. Paton of National University of Singapore (NUS). We
thank S. Phyu, M. Gengenbacher and Low J.L. of NUS for BSL3
core and lab management support. Dr. D. Alland (Rutgers
University, New Jersey Medical School) for the piniBAC reporter
plasmid, and Dr. Y. Yamada (NUS) for providing a modified
version of the M. bovis BCG-piniBAC-RFP strain.
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ABBREVIATIONS
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BCG, Bacillus Calmette-Guerin; CCCP, carbonyl cyanide m-
chlorophenyl hydrazone; DiOC2, 3,3′-diethyloxacarbocyanine
iodide; Log P, logarithm to base 10 of partition coefficient P;
MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bro-
mide; PI, propidium iodide; RFP, red fluorescent protein; TPP,
triphenylphosphonium
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