KALEDINA et al.
1632
Baltina, L.A., Galin, F.Z., and Tolstikov, G.A., Russ.
J. Bioorg. Chem., 2003, vol. 29, p. 296.
agglutination of erythrocytes. The titre was expressed in
logarithm of the 50% of the infective dose (log ID50).
The antiviral activity of a compound was estimated
from the decreased infective titre of the virus. From the
data obtained the 50% effective concentration was
calculated, or the concentration of the compound
which caused the two-fold reduction of the virus titre
(by 0.3 log ID50) (EC50), and then the selectivity index
SI was calculated (the ratio CTD50/EC50).
9. Flekhter, O.B., Boreko, E.I., Nigmatullina, L.R.,
Pavlova, N.I., Medvedeva, N.I., Nikolaeva, S.N.,
Tret’yakova, E.V., Savinova, O.V., Baltina, L.A.,
Karachurina, L.T., Galin, F.Z., Zarudii, F.S., and
Tolstikov, G.A., Pharm. Chem. J., 2004, vol. 38, p. 148.
10. Flekhter, O.B., Medvedeva, N.I., Tolstikov, G.A.,
Savinova, O.V., Boreko, E.I., and Dolgushin, F.M.,
Russ. J. Bioorg. Chem., 2009, vol. 35, p. 118.
Spectral measurements were performed in the
Resource centers “Magnetic Resonance Research
Centre” and “Chemical Analysis and Materials Research
Centre” of the St. Petersburg State University.
11. Kazakova, O.B., Giniyatullina, G.V., and Tolstikov, G.A.,
Russ. J. Bioorg. Chem., 2011, vol. 37, p. 619.
12. Kazakova, O.B., Giniyatullina, G.V., Tolstikov, G.A.,
Baikova, I.P., Zaprutko, L., and Apryshko, G.N., Russ.
J. Bioorg. Chem., 2011, vol. 37, p. 369.
13. Antimonova, A.N., Uzenkova, N.V., Petrenko, N.I.,
Shakirov, M.M., Shul’ts, E.E., and Tolstikov, G.A.,
Russ. J. Org. Chem., 2011, vol. 47, p. 589.
The study was carried out under the financial
support of the Russian Science Foundation (project
no. 14-50-00069).
14. Ukiya, M., Kikuchi, T., Tokuda, H., Tabata, K.,
Kimura, Y., Arai, T., Ezaki, Y., Oseto, O., Suzuki, T.,
and Akihisa, T., Chem. Biodiv., 2010, vol. 7, p. 1871.
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RUSSIAN JOURNAL OF ORGANIC CHEMISTRY Vol. 51 No. 11 2015