Journal of Medicinal Chemistry p. 1411 - 1413 (1995)
Update date:2022-08-16
Topics:
Stowell, John C.
Huot, Rachel I.
Voast, Lainie Van
We have developed a practical synthesis of N-hydroxy-N'-phenyloctanediamide from the methyl ester of suberanilic acid.It provides the product in high yield and purity with a simple purification process.We have found that at 10-5 M it has a dramatic effect on T/5 AXC/SSh rat prostate cancer cells in vitro.It is a potent inhibitor of cell proliferation and it changes the cell morphology to resemble nonmalignant cells.
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