Bioorganic and Medicinal Chemistry Letters p. 5247 - 5250 (2004)
Update date:2022-08-30
Topics:
Reigan, Philip
Gbaj, Abdul
Chinje, Edwin
Stratford, Ian J.
Douglas, Kenneth T.
Freeman, Sally
A series of xanthine oxidase-activated prodrugs of known inhibitors of thymidine phosphorylase are described. These prodrugs were oxidised by xanthine oxidase at C-2 and/or C-4 of the uracil ring to generate the desired TP inhibitor. The scheme shows the prodrug of TPI. A series of xanthine oxidase-activated prodrugs of known inhibitors of thymidine phosphorylase has been designed and synthesised to introduce tumour selectivity. These prodrugs were oxidised by xanthine oxidase at C-2 and/or C-4 of the uracil ring to generate the desired TP inhibitor.
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