Tetrahedron Asymmetry p. 2453 - 2464 (1997)
Update date:2022-08-16
Topics:
Skupin, Rolf
Cooper, Trevor G.
Froehlich, Roland
Prigge, Joerg
Haufe, Guenter
The resolution of the enantiomers of the chemotherapeutic Ornidazole (Tiberal) 1a was achieved by acetylation of the racemic compound with vinylacetate in the presence of lipase Amano PS (from Pseudomonas cepacia). The halogen analogues 4a-6a and the corresponding 4-nitro-derivatives 1b and 4b-6b were also synthesized and the enantiomers were separated by kinetic enzymatic resolution. The absolute configuration of two compounds was determined by X-ray crystallography.
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