Chemistry - A European Journal
10.1002/chem.201805318
solution. The backbone N-modification method was also applied to
the synthesis of peptides with self-inducing -helix featuring HBS
structures. For this, the covalent connectivity was established
between the N-substituent of an internal amide and the N-terminus,
thus mimicking the intramolecular hydrogen bond occurring in -
helices. The versatility and efficacy of this backbone stapling
approach makes it suitable for application in the parallel synthesis and
screening of cyclic peptides based on bioactive sequences.
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Published online on ((will be filled in by the editorial staff))
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Keywords: peptide cyclization • multicomponent reactions • stapled
peptides • -helix • macrocycles
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