Heterocycles p. 2783 - 2790 (2005)
Update date:2022-08-17
Topics:
Yli-Kauhaluoma, Jari
Laine, Aki
Ratilainen, Jari
Karjalainen, Arto
A facile method for the preparation of conformationally rigid analogues of the adrenergic α-2 receptor antagonist atipamezole and the adrenergic α-2 receptor agonist medetomidine has been developed. The efficient benzyne [4+2] cycloaddition reaction was used to give the core 7-acetylbenzonorbornadiene structure, which was subsequently elaborated to the corresponding imidazole-based syn and anti isomers by means of the classical Bredereck's method.
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