Magnetic Resonance in Chemistry p. 337 - 341 (1997)
Update date:2022-08-11
Topics:
Moloney, Gerard P.
Iskander, Magdy N.
Craik, David J.
Condensation of (-)-norephedrine with excess formaldehyde under mild conditions leads to formation of the 2:1 condensation product N,N'-methylenebis(4-methyl-5-phenyl)oxazolidine compared with the reaction with 1 mol of formaldehyde, which leads to 4-methyl-5-phenyloxazolidine. 1H and 13C NMR spectroscopy was used to monitor the stability of this compound and its decomposition products. The 2:1 condensation product is found to be stable in CDC13 but breaks down rapidly in CD3OD to yield a 50:50 mixture of 4-methyl-5-phenyloxazolidine and 3-hydroxymethyl-4-methyl-5-phenyloxazolidine. Upon addition of D2O to this equimolar mixture, the latter compound decomposes to norephedrine and formaldehyde, whereas the former compound is stable.
View MoreContact:+86-0760-85282375
Address:zhongjing road,zhongshan torch hi-tech industrial development zone
Jinan Yijialian Economic and Trade Development Co., Ltd.
Contact:+86 0531-66729596
Address:jinan
Shanghai Mio Chemical Co., Ltd
Contact:0086 21- 64401188-622
Address:16 Floor NO.2 Jiefang Building, No. 4855 Dushi Road, 201100 Shanghai, P.R.China
Chengdu NoVi Biotechnology Co., Ltd.
Contact:13551243286/028-81458053
Address:NO.168-1-224 JULONG ROAD WUHOU DISTRICT, CHENGDU CITY,SICHUAN PROVINCE
Zhejiang Linhai Xinhua Chemicals Factory
Contact:0086-13661858911
Address:Xunqiao Development Zone, Linhai, Zhejiang, China
Doi:10.1016/j.cplett.2007.11.051
(2008)Doi:10.1016/j.bmcl.2016.12.027
(2017)Doi:10.1021/jacs.7b03005
(2017)Doi:10.1016/S0040-4020(97)01063-6
(1997)Doi:10.1039/c6cc08240h
(2016)Doi:10.1021/ja01156a085
(1951)