Journal of the American Chemical Society
(SPR/2019/000158). HK, SKD and SR thank CSIR for their SRF.
Page 6 of 7
is that if the amination follows an electrophilic mechanism,
substrate (1e) having a stronger C–H bond (BDE = 99
Kcal/mol) would produce more product formation.22,24
Likewise, if the amination follows a radical activation
mechanism, substrate (1f) having a relatively weaker C–H
bond (BDE = 90 Kcal/mol) would generate more product
formation. However, what we observed is that substrate (1f)
has a strong preference for the amination providing more
product formation compared to the substrate (1e), which
demonstrates that the C(sp3)–H amination follows a radical
activation mechanism.
1
2
3
4
5
6
7
8
BC thanks to the SERB for Science and Technology Award for
Research. We also thank CBMR for research facilities.
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To shed more light on the proposed mechanism, we designed
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ASSOCIATED CONTENT
Supporting Information Available: Full characterization, copies
of all spectral data, experimental procedures. This material is
AUTHOR INFORMATION
Corresponding Author
buddhadeb.c@cbmr.res.in, buddhachem12@gmail.com
Author Contributions
SKD and SR contributed equally.
Notes
The authors declare no competing financial interest.
ACKNOWLEDGMENT
This
work
was
supported
SERB-STAR
and
by
SERB-CRG
AWARD
grant
grant
grant
(CRG/2018/000133),
(STR/2019/000045)
SERB-SUPRA
6
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