Journal of Medicinal Chemistry p. 2871 - 2876 (1991)
Update date:2022-08-15
Topics:
Fukuto
Kumagai
Cho
The mechanism of demethylenation of (methylenedioxy)benzene (MDB), (methylenedioxy)amphetamine (MDA), and (methylenedioxy)methamphetamine (MDMA) by purified rabbit liver cytochrome P450IIB4 has been investigated by using deuterium isotope effects. A comparison of the magnitude and direction of the observed kinetic isotope effects indicates that the three compounds are demethylenated by different mechanisms. The different mechanisms of demethylenation have been proposed on the basis of comparisons of the observed biochemical isotope effects with the isotope effects from purely chemical systems.
View Morewebsite:http://www.zhenfeichem.com
Contact:15318988277
Address:Weicheng District,Weifang City,Shandong Province
Chemtrade International ( China )
Contact:+86-532-86893005
Address:Rm 2-501, Huaxia Zonghe Building, No. 410 JInggangshan Road, Huangdao
TAIXING BEST NEW MATERIALS CO., LTD
Contact:0523-87998158;
Address:No.18 Zhonggang Road,Taixing City ,Jiangsu , China
HaiNan Periwinkle Pharmaceutical Co.,Ltd.
website:http://www.cchpharm.com/en/index.html
Contact:020-82208978
Address:Gongye road,Wuzhishan city,HaiNan province
Contact:86-574-83851061 86-574-87083208
Address:Room 905, No.3 Building,East Business Center, 456 Xingning Road, Ningbo City,China
Doi:10.1021/jo00006a008
(1991)Doi:10.1002/jhet.2920
(2017)Doi:10.1007/BF00957408
()Doi:10.1021/acs.joc.5b02333
(2015)Doi:10.1039/c5tb01150g
(2015)Doi:10.1021/jacs.7b10010
(2017)