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Acknowledgments
We gratefully acknowledge C. Meier (Universita¨t Hamburg, Ham-
burg, Germany) for kindly providing ribavirin. We thank S. Sarfati
(Unite´ de Chimie Organique, Institut Pasteur) for initial input in the
work and Ce´line Boulard for excellent technical assistance. We are
deeply indebted to Sonia Longhi for mutagenesis experiments to
reduce the number of rare codons in the HCV polymerase cDNA.
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Address correspondence to: Dominique Deville-Bonne, Re´gulation Enzy-
matique des Activite´s Cellulaires, Departement Biologie Structurale et
Chimie, Institut Pasteur, 25 rue du Dr. Roux 75724, Paris Cedex 15 France.
E-mail: ddeville@pasteur.fr
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