Bioorganic and Medicinal Chemistry Letters p. 555 - 560 (1997)
Update date:2022-08-25
Topics:
Chen, Huai G.
Chung
Goel
Johnson
Kesten
Knobelsdorf
Lee
Rubin
A practical and scalable total synthesis of tachykinin NK3 receptor antagonist SR 142801, (R)-N-[1-[3-[1-benzoyl-3-(3,4-dichlorophenyl)-3-piperidinyl]propyl]-4-phenyl-4 -piperidinyl]-N-methyl acetamide 1 is described. The absolute configuration of the key intermediate 7 was determined by single crystal X-ray crystallography, on the basis of which, the absolute configuration of SR 142801 should be (R)-(+), instead of the recently reported (S)-(+).
View Morewebsite:http://www.eastarchem.com/
Contact:1-800-898-2436
Address:1215 K Street, STE 1700
Contact:+86-134-5286-9121
Address:Add: Wing Tuck Commercial Centre, 177-183 Wing Lok Street, Hong Kong,
SEA BRGIHT INDUSTRY CO.,LIMITED
Contact:0086 755 8622 3990
Address:Rm 17B3,GuangCaiXinTianDi Bldg,GuiMiao Rd,NanShan District,Shenzhen,China
Contact:13813902930 025-52714267
Address:20 Fengji Road, Yuhua Economic Development Zone, Nanjing, Jiangsu, P. R. China
shanghai jinshan pharmaceutical Co.,Ltd
Contact:021-57363011,13681638167
Address:No. 7966 Tingfeng Road,Jinshan,Shanghai,China
Doi:10.1021/ol015823n
(2001)Doi:10.1021/ja01232a019
(1944)Doi:10.1021/jo01065a082
(1961)Doi:10.1080/00304948.2017.1343037
(2017)Doi:10.1021/ja953416z
(1996)Doi:10.1039/c39950000519
(1995)