Tetrahedron Letters p. 217 - 220 (1991)
Update date:2022-08-10
Topics:
Aoki, Masahiro
Ohtsuka, Tatsuo
Itezono, Yoshiko
Yokose, Kazuteru
Furihata, Kazuo
Seto, Haruo
Cyclothiazomycin is a novel renin inhibitor produced by Streptomyces sp.NR 0516 (IC50 1.66μM).Its molecular formular was determined to be C59H64N18O14S7 (MW. 1472) based on high-resolution FAB mass and NMR spectroscopy.Five fragments of cyclothiazomycin containing thiazole, thiazoline, heterocyclic chromophore were clarified by extensive 2D-NMR experiments.
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