Synthesis and crystal structure of 2-benzoyl-4-methyl phenyl benzoate
467
5. Evans, D.; Cracknell, M.E.; Saunders, J.C.; Smith; C.E.; Nigel,
W.R.; Willamson, N.W.R.; Dowson, W.; John, F.; Sweatman,
W. J. Med. Chem. 1987, 30, 1321–1327.
6. Brancaccio, G.; Angelo; Larizza; Lettier, G. J. Med. Chem.
1981, 24, 998–1000.
7. Schlitzer, M.; Bohm, M.; Sattler, I. Bioorg. Med. Chem. 2002,
10, 615.
8. Sakowski, J.; Bohm, M.; Sattler, I.; Dahse, H.M.; Schlitzer, M.
J. Med. Chem. 2001, 44, 2086.
unusual discrepancy between the carbonyl group
˚
---
bond lengths of ketone (C8 O7:1.218(2) A) and
˚
---
ester (C18 O17:1.200(2) A) group. This change
can be attributed due to strong resonance of keto
carbonyl group. The keto and ester groups in the
structure are important determinants for some po-
tent biological activities.5,6,11,12
9. Leonard, D.M. J. Med. Chem. 1997, 40, 2971; Williams, T.M.;
Dinsmore, C.J. Adv. Med. Chem. 1999, 4, 273.
10. Palomer, A.; Pascual, J.; Cabre, M.; Borras, L.; Gonzalez, G.;
Aparici, M.; Carabaza, A.; Cabre, F.; Garcia, M.L.; Mauleon,
D. Bioorg. Med. Chem. Lett. 2002, 12, 533.
11. Khanum, S.A.; Shashikanth, S.; Deepak, A.V. Bioorg. Chem.
2004, 32, 211.
12. Khanum, S.A.; Venu, T.D.; Shashikanth, S.; Firdouse, A.
Bioorg. Med. Chem. Lett. 2004, 14, 5351.
Supplementary material CCDC-213702 contains the supplemen-
tary crystallographic data for this paper. These data can be obtained
the Cambridge Crystallographic Data Centre (CCDC), 12 Union
Road, Cambridge CB2 1EZ, UK; fax: +44(0)1223-336033; e-mail:
13. Wiesner, J.; Mitsch, A.; Wibner, P.; Jomaa, H.; Schlitzer, M.
Bioorg. Med. Chem. Lett. 2001, 9, 785.
14. Wiesner, J.; Kettler, K.; Jomaa, H.; Schlitzer, M. Bioorg. Med.
Chem. Lett. 2002, 12, 543.
Acknowledgments
15. Thomas, G.; Andreas, G.; Joachim, R.; Ingo, R.; Peter, S.; Frank,
S.; Norbert, G.; Karl, E.; Eberhard, A.; Siegfried, S.; Gisela, L.;
Reinhard, S. Chem. Abstr. 2002, 137, 232443.
16. Ke, L.; Wannian, Z.; Wu, Z.; Xiaoyan, W. Zhongguo Yiyao
Gongye Zazhi 2001, 32, 115.
17. Liou, G.P.; Chang, C.W.; Song, J.S.; Yang, Y.N.; Yeh, C.F.;
Tseng, H.Y.; Lo, Y.K.; Chang, Y.L.; Chang, C.M.; Hsieh, H.P.
J. Med. Chem. 2002, 45, 2556.
18. Nakagawa, Y.; Suzuki, T.; Tayama, S. Toxicology 2000, 156,
27.
The authors would like to express their
thanks to DST, Government of India for finan-
cial assistance under the project SP/I2/FOO/93.
Also the author Mahendra, would like to thank
CSIR, Government of India, for awarding Senior
Research Fellowship.
19. Qianghua, W.; Baojun, Q. J. Appl. Polym. Sci. 2002, 85, 1581.
20. Lajos, A.; Rene, B.; Victor, S. PCT Int. WO 2002064580 A1,
2002. Through Chem. Abstr. 2002, 137, 187276.
21. Kadry, A.M.; Okereke, C.S.; Abdel-Rahman, M.S.; Friedman,
M.A.; Davis, R.A. J. Appl. Toxicol. 1995, 15, 97.
22. Sheldrick, G.M. SHELXS-97; University of Go¨ttingen:
Germany, 1997.
References
1. Wyatt, P.G.; Bethell, R.C.; Cammack, N.; Charon, D.; Dodie,
N.; Dumaitre, B.; Evans, D.N.; Darren, V.; Green, S.; Hopwell,
P.L.; Humber, D.C.; Lamont, R.B.; Orr, D.C.; Plested, S.J.;
Ryan, D.M.; Sollis, S.L.; Storer, R.; Weingarten, G.G. J. Med.
Chem. 1995, 38, 1657–1665.
23. Sheldrick, G.M. SHELXL-97; University of Go¨ttingen:
Germany, 1997.
24. Otwinowski, Z.; Minor, W. Processing of X-ray Diffraction
Data Collected in Oscillation mode. In Methods in Enzymology,
Volume 276: Macromolecular Crystallography, part A; Carter,
C.W. Jr.; Sweet, R.M., Eds.; Academic Press: New York, 1997;
pp. 307–326
25. Johnson, C.K. ORTEP-II. A Fortran Thermal-Ellipsoid Plot
Program. Report ORNL-5138; Oak Ridge National Laboratory:
Oak Ridge, Tennessee, USA, 1976.
2. Hsieh, H.P.; Liou, J.P.; Lin, Y.T.; Mahindroo, N.; Chang, J.Y.;
Yang, Y.N.; Chern, S.S.; Tan, U.K.; Chang, C.W.; Chen, T.W.;
Lin, C.H.; Chang, Y.Y.; Wang, C.C. Bioorg. Med. Chem. Lett.
2003, 13, 101.
3. Wiesner, J.; Kettler, K.; Jomaa, H.; Schlitzer, M. Bioorg. Med.
Chem. Lett. 2002, 12, 543.
4. Palaska, E.; Sahin, G.; Kelicen, P.; Durllu, N.T.; Altinok, G. IL
Farmaco 2002, 57, 101.