Synthetic Communications p. 529 - 532 (1994)
Update date:2022-08-11
Topics:
Mason
Milner
Nitration of inexpensive 1,2,4-trichlorobenzene gave 2,4,5- trichloronitrobenzene (90%) which was treated with KF to form 2,4-difluoro- 5-chloronitrobenzene (70%). This was selectively hydrogenated over Pd / C to give 2,4-difluoroaniline (80%). Deamination afforded 1,3-difluorobenzene. The sequence avoids the need for costly 1,3-dichlorobenzene.
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(2019)