Synthetic Communications p. 2034 - 2040 (2021)
Update date:2022-08-16
Topics:
He, Chasheng
Zhai, Ziran
Zhou, Yang
Li, Jianqi
Wang, Guan
We reported the synthesis of (S)-pregabalin in a five-step sequence with 20% overall yield. As a modification of the previously developed route, a Michael addition between CH3NO2 and chiral oxaoxazolidinone was employed as a key operation for introducing the methyleneamino group, which allowed avoiding the use of toxic cyanide reagent and led to enantiomerically pure product (>99% ee) after the recrystallization in appropriate solvent.
View MoreLinHai Cina Chemical Co., LTD.
Contact:0576-85580989
Address:Pharma-chem zone,Duqiao,Linhai,Zhejiang,China
Henan PURUI Pharmaceutical Co., Ltd.
website:http://www.puruipharm.com
Contact:17739583555
Address:Yezhuangqiao,Xihua town, Henan province
MOKESI TECHNOLOGY CO., LIMITED
Contact:000000000000
Address:NO.168 ,Weisi Road, Zhengzhou City,Henan,China
JinTan Pingsheng Chemical Co.,Ltd
Contact:+86-519-82828200
Address:NO.11Danfengxilu Road,Jintan City,Jiangsu,China
website:http://www.sjzthld.com
Contact:86-311-66699812
Address:NO.600 ZHONGSHAN EAST ROAD SHIJIAZHUANG
Doi:10.1002/ejoc.200700831
(2007)Doi:10.1039/c7nj04964a
(2018)Doi:10.1055/s-2006-950273
(2006)Doi:10.1039/TF9504601019
(1950)Doi:10.1055/s-0034-1380191
(2015)Doi:10.1080/10610278.2016.1167210
(2017)