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131.78, 131.89, 139.47, 140.04, 141.03, 152.12, 152.82,
160.09 ppm; MS (70 ev), m/e: 356[ M+].
1
[10]
Table 2, entry 9: M.p. = 154-155°C; H NMR (CDCl3,
TMS, 250 MHz): ꢀ 3.69 (s, 4H); 7.2-7.32 ( m, 6H); 7.38 (d,
J=6.5, 4H) ppm; 13C NMR (CDCl3, TMS, 62.9 MHz): 45.79,
128.1, 128.41, 129.62, 137.73, 160.29 ppm; MS (70 ev),
m/e: 234[ M+].
Table 2, entry 10: M.p. = 114-115°C; 1H NMR (CDCl3,
TMS, 250 MHz): ꢀ 3.63 (s, 4H); 3.78 (s, 6H); 6.75 ( d,
J=8.25 4H); 7.34 (d, J= 8.25, 4H) ppm; 13C NMR (CDCl3,
TMS, 62.9 MHz): 45.68, 55.23, 113.45, 129.56, 130.51,
159.58, 160.68 ppm; MS (70 ev), m/e: 294[ M+].
[11]
[12]
[13]
[14]
CONCLUSIONS
In this study, a simple and eco-friendly method for the
efficient synthesis of quinoxaline derivatives via the
condensation reaction of 1,2-diamines and 1,2-dicarbonyl
compounds in EtOH as a standard green solvent under mild
conditions is introduced. The solvent nature and reactant
concentration have crucial effects on the yield of products
and reaction times. It was explored that the condensation
reaction was efficiently enhanced under the influence of
ZrOCl2.8H2O as a green and reusable catalyst in ethanol
under mild conditions.
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A practical and efficient synthesis of quinoxaline
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ACKNOWLEDGEMENT
[19]
[20]
Support for this work by Research Council of University
of Birjand is highly appreciated.
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