Bioorganic and Medicinal Chemistry p. 3542 - 3551 (2015)
Update date:2022-08-28
Topics:
Yadav, Arun A.
Chee, Gaik-Lean
Wu, Xing
Patel, Daywin
Yalowich, Jack C.
Hasinoff, Brian B.
Drugs that target DNA topoisomerase II, such as the epipodophyllotoxin etoposide, are a clinically important class of anticancer agents. A recently published X-ray structure of a ternary complex of etoposide, cleaved DNA and topoisomerase IIβ showed that
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