convert into tubular structures. The rather high tempera-
ture would be necessary for the solubilization of 1, allowing
its progressive incorporation into the DOPC membranes
and the resulting self-assembly of micrometre-diameter
tubes. Higher temperatures and/or longer incubation times
might then increase the amount of incorporated cholesteryl-
uridine, leading to the formation of nanometre-diameter
tubes.
Notes and references
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2
could also be confirmed by H NMR spectra of lipid micro-
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2
spectra showed no significant differences, suggesting similar
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,
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´
´
tubes are characteristic for a rather unperturbed lamellar
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´
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This work was supported by a grant from the Federal
Ministry of Education and Research (BMBF 0312027). We
thank the German Research Foundation and the Experi-
mental Physics Institutes of the University of Leipzig for
measuring time on the Avance 750 MHz NMR spectrometer.
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¨
ꢀc
This journal is The Royal Society of Chemistry 2010
5360 | Chem. Commun., 2010, 46, 5358–5360