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immersion in the buffer and after that time weight loss was found
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4. Conclusion
Poly(ester-anhydride) copolymers, based on succinic acid and
1,6-bis-p-carboxyphenoxyhexane were obtained and character-
ized. The poly(ester-anhydride)s obtained with different amount
of OSAGE and CPH, differ in their solubility and thermal properties.
The studies indicate that poly(CPH) and its copolymers with
OSAGE have vastly different degradation rate and mode depending
on the content of both prepolymers. They could be considered as
potential biodegradable carriers for controlled release of drugs.
The amorphous state of most the copolymers and their glass tem-
perature below room temperature are desirable for processing into
tablets. Solubility of copolymers with higher amount of CPH in
chlorinated solvent could allow to be fabricated into micro or
nanospheres.
The obtained polymers contain allyl groups in the side chains,
which could be used for copolymerization or modification. Due
to solubility of some copolymers in methyl methacrylate, the
application of poly(ester-anhydride)s in biodegradable bone ce-
ments could be also taken into consideration.
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Acknowledgements
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Financial support from the Polish State Committee for Scientific
Research (Grant No. N205 016534).
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