4
Table 3: Recyclability of CuF2O4 Nanoparticlesa
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aReaction conditions: Benzo[d]thiazole ( 1.0 mmol), Aryl iodide
(1.5 mmol), CuFe2O4 nanoparticles (0.05 mmol), PPh3 (0.02 mmol),
K3PO4 (1.5-2 mmol), DMSO (3 mL), 110 oC, 10 h.
4. (a)Wang, X.; Sarris, K.; Kage, K.; Zhang, D.; Brown, S. P.;
Kolasa T.; Surowy, C.; Kouhen, O. F. E.; Muchmore, S. W.;
Brioni, J. D.; Stewart, A. O. J. Med. Chem. 2009, 52,
The recyclability of the CuFe2O4 nano catalyst was examined and the
results are summarized in Table 3. To check the recyclability of the
catalyst, after completion of the reaction, CuFe2O4 nano particles
were separated by a neodymium magnet, The separated nano catalyst
was washed successively with 10 mL of water, ethanol, ethyl acetate,
dichloromethane, and hexane, and then dried. In a typical recycling
experiment, more than 92% of CuFe2O4 nano could be recovered.
The native and used CuFe2O4 nanoparticles were analyzed by TEM,
SEM and powder XRD analysis. It was observed from the TEM
studies (Fig. 2.) (Supp. information) that the used CuFe2O4
nanoparticles were intact in size and shape even after four cycles.
From SEM studies (Fig. 3.) (Supp. information) it was observed that
the morphology of the catalyst did not change after four cycles. The
powder XRD spectra (Fig. 4.) (Supp. information) also confirmed
the near intactness of the catalyst after four cycles. The XRD spectra
indicate the tetragonal structure of CuFe2O4.18
5.
Mortimer, C. G.; Wells, G.; Crochard, J.-P.; Stone, E. L.;
Bradshaw, T. D.; Stevens, M. F. G.; Westwell, A. D. J. Med.
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R.; Stevens, M. F. G.; Matthews, C. S.; Bradshaw, T. D.;
Westwell, A. D.; J. Med. Chem. 2008, 51, 5135.
7. Itai, A.; Muto, S.; Tokuyama, R.; Fukazawa, H.; Ohara, T.; Kato,
T. WO 2007023882, 2007.
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Conclusion:
In conclusion, we have shown that benzothiazoles and iodo benzene
react effectively under the catalysis of magnetically recoverable and
10. A. Tehim, B. Herbert, T. M. Nguyen, W. Xie, C. M. Gauss, WO
2004029050, 2004.
recyclable CuFe2O4
phenylbenzo[d]thiazole.
nanoparticles
to
obtain
2-
11. (a) de Meijere, A.; Diederich, F. Metal-Catalyzed Cross-Coupling
Reactions, 2nd ed.; Wiley-VCH: Weinheim, 2004; (b) Tsuji, J.
Palladium Reagents and Catalysts, 2nd ed.; John Wiley & Sons:
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Acknowledgments
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D.; Scott, M. E.; Lautens, M. Chem. Rev. 2007, 107, 174; (c)
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Hassan, J.; Se vignon, M.; Gozzi, C.; Schulz, E.; Lemaire, M.
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We are grateful to CSIR, New Delhi, for research fellowships to
G.S, K.H.V.R, and B.S.P.A.K, K.R and to the UGC, New Delhi, for
fellowship to R.U.K.
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17. Representative experimental procedure for the synthesis of 2-
phenylbenzo[d]thiazole: