Synthesis p. 861 - 863 (1993)
Update date:2022-08-11
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The excitatory amino acid 2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid (AMPA) has been prepared in gram quantities in 42% total yield by a three-step procedure from 3-hydroxy-5-methylisoxazole. It is shown how bromomethylation may be optimized through control of the involved equilibria and how N-protecting methoxymethyl groups can be removed.
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Doi:10.1016/j.tet.2012.09.019
(2012)Doi:10.1002/chem.202001051
(2020)Doi:10.1039/DT9790000228
()Doi:10.1021/cm903444n
(2010)Doi:10.1016/j.apcata.2011.01.014
(2011)Doi:10.1021/ic5003226
(2014)
