Bioorganic and Medicinal Chemistry Letters p. 1335 - 1338 (1996)
Update date:2022-08-10
Topics:
Liu, Lee Tai
Lin, Ya-Chuan
Wang, Chia-Lin J.
Lin, Mei-Shey
Yen, Su-Chen
Chen, Hsiao-Jen
A series of novel 1,2,3,4-tetrahydroisoquinoline derived azoles has been designed and synthesized as antifungal agents which might function as inhibitors of cytochrome P-450 dependent lanosterol 14α-demethylase. In vitro tests showed that some of these compounds, especially 5b and 6b, effectively inhibit the growth of several strains of yeasts as well as molds.
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