Beilstein Journal of Organic Chemistry p. 1863 - 1868 (2020)
Update date:2022-08-17
Topics:
Kiskin, Mikhail A.
Taydakov, Ilya V.
Diethyl 2-(perfluorophenyl)malonate was synthesized in 47% isolated yield by the reaction of sodium diethyl malonate and hexafluorobenzene. The resulting compound was considered as a starting material for synthesizing 2-(perfluorophenyl)malonic acid by hydrolysis. It was found that the desired 2-(perfluorophenyl)malonic acid could not be obtained from this ester by hydrolysis, neither under basic nor under acidic conditions. Nevertheless, hydrolysis of the ester with a mixture of HBr and AcOH gave 2-(perfluorophenyl)acetic acid in a good preparative yield of 63%. A significant advantage of this new approach to 2-(perfluoro-phenyl)acetic acid is that handling toxic substances such as cyanides and perfluorinated benzyl halides is avoided.
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Doi:10.1007/BF00505702
(1981)Doi:10.1039/c9tb00769e
(2019)Doi:10.1002/chem.202100677
(2021)Doi:10.1359/jbmr.2002.17.5.845
(1954)Doi:10.1021/jo00445a036
(1977)Doi:10.1021/ja01397a018
(1928)