Room temperature Suzuki–Miyaura reactions of aryl halides
The services of SAIF IIT Madras are also acknowledged for NMR
and mass spectra facilities.
Table 5. Suzuki–Miyaura cross-coupling reactions of various aryl
chlorides with phenylboronic acid using Pd(OAc)2 –L1 catalysta
Supporting Information
Supplimentary information containing characterization informa-
tion on all the known compounds are available in the online
version of the article.
References
Entry
R
Time (h)
Yield (%)b,c
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1
2
3
4
5
6
7
8
4-NO2
4-COMe
4-CHO
4-COOH
H
36
36
36
36
48
48
48
48
78
64
52
60
52
47
42
32
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i
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b
Isolated yield.
Yields are of average of two runs.
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[
In conclusion, we have developed a simple catalytic system
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bromides with arylboronic acids. Good-to-excellent yields of the
coupling products were obtained at room temperature using
neat water as solvent. The efficiencies of the ligands follow the
order (C6H5)3CNH2 > C6H5CH2 NH2 > C6H5 NH2 > C6H11 NH2,
which is consistent with the palladacycle-forming capacity of the
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Acknowledgments
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The University Grants Commission, New Delhi, is gratefully
acknowledgedforfundingthiswork(grantno.36-73/2008,SR)and
also for providing a fellowship to C.S. under the RFSMS scheme.
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Appl. Organometal. Chem. 2011, 25, 283–288
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