Tetrahedron p. 11135 - 11144 (1993)
Update date:2022-08-05
Topics:
Gould
Cheng
The labelling pattern obtained from incorporation of a mixture of sodium [1-13C]- and [2-13C]acetates has confirmed the irregular derivation of the benz[a]anthraquinone skeleton of the angucycline antibiotic PD 116198. Subsequent incorporations of sodium [1-13C, 18O2]-, and [1-13C, 2-2H3]acetates and of 18O2 have revealed the origins of the hydrogen and oxygen atoms of the antibiotic. The possibility of a 'two-chain' biosynthesis was tested by feeding 2H-labeled orsellinates; however, no incorporation was detected. PD 116198 seems most plausibly derived by rearrangement of an initially-formed linear tetracyclic intermediate.
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